Studies on the antiproliferative effects of tropolone derivatives in Jurkat T-lymphocyte cells.
Basic Information
ID: ALA3232980
Journal: Bioorg Med Chem
Title: Studies on the antiproliferative effects of tropolone derivatives in Jurkat T-lymphocyte cells.
Authors: Ononye SN, Vanheyst MD, Giardina C, Wright DL, Anderson AC.
Abstract: Thujaplicins are tropolone-derived natural products with antiproliferative properties. We recently reported that certain tropolones potently and selectively target histone deacetylases (HDAC) and inhibit the growth of hematological cell lines. Here, we investigated the mechanisms by which these compounds exert their antiproliferative activity in comparison with the pan-selective HDAC inhibitor, vorinostat, using Jurkat T-cell leukemia cells. The tropolones appear to work through a mechanism distinct from vorinostat. These studies suggest that tropolone derivatives may serve as selective epigenetic modulators of hematological cells with potential applications as anti-leukemic or anti-inflammatory agents.
CiteXplore: 24613456
DOI: 10.1016/j.bmc.2014.02.018
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