Document Report Card

ID: ALA3244022

Journal: J Med Chem

Title: Total syntheses of (+/-)-1-carbacefoxitin and -cefamandole and (+/-)-1-oxacefamandole.

Authors: Firestone RA, Fahey JL, Maciejewicz NS, Patel GS, Christensen BG.

Abstract: The total syntheses of the (+/-)-1-carba analogues of cefoxitin (11), 7 alpha-methoxydeacetylcephalothin (5) and cefamandole (31) and the (+/-)-1-oxa analogue of cefamandole (43) are described. Their bioactivity spectra against 14 typical organisms are similar to those of their natural 1-thia counterparts, with the 1-carba compounds somewhat less active and the 1-oxa compound more active than the natural ones.

CiteXplore: 850241

DOI: 10.1021/jm00214a018