Basic Information
ID: ALA3244068
Journal: J Med Chem
Title: Structure-activity relationships in antitumor aniline mustards.
Authors: Panthananickal A, Hansch C, Leo A.
Abstract: Quantitative structure-activity relationships (QSAR) have been formulated for the hydrolysis of aniline mustards and their antitumor activity against Walker 256 tumor and L1210 and P388 leukemia. In general, the antitumor activity parallels hydrolysis under the conditions defined by Ross; toxicity (LD50) parallels antitumor efficacy. Chlorambucil is an exception. A most important finding is that ideal lipophilicity for effectiveness against Walker tumor appears to be much higher than for the leukemias which suggests that solid tumors may, in general, require more lipophilic drugs than leukemias.
CiteXplore: 619146
DOI: 10.1021/jm00199a004
Patent ID: ┄
Associated Items: Associated Bioactivities Associated Assays Associated Compounds Associated Targets