Document Report Card

ID: ALA3244074

Journal: J Med Chem

Title: 2-Indanpropionic acids: structural leads for prostaglandin F2alpha antagonist development.

Authors: Witiak DT, Kakodkar SV, Johnson TP, Baldwin JR, Rahwan RG.

Abstract: A rationale is presented for the development of prostaglandin F2alpha receptor antagonists. The target analogue, 5,6-(dibenzyloxy)-1-oxo-2-propyl-2-indanpropionic acid (3), was shown to have selective activity for antagonism of PGF2alpha when compared to the antagonism of acetylcholine and KCl on the mouse ileum, whereas other 2-indanpropionic acids (1, 2, 4), not substituted with benzyl functions, were considerably less active and nonselective. The results suggest that 3 may serve as a lead compound for further drug development.

CiteXplore: 423186

DOI: 10.1021/jm00187a017