Synthesis and antiarrhythmic activity of 2-dialkylaminoalkyl-9-phenyl-1H-indeno[2,1-c]pyridine derivatives.

Basic Information

ID: ALA3244079

Journal: J Med Chem

Title: Synthesis and antiarrhythmic activity of 2-dialkylaminoalkyl-9-phenyl-1H-indeno[2,1-c]pyridine derivatives.

Authors: Ellefson CR, Woo CM, Cusic JW.

Abstract: Some dihydro- and hexahydro-2-dialkylaminoalkyl-9-phenyl-1H-indeno[2,1-c]pyridines were prepared and found to possess significant antiarrhythmic activity. Hydrogenation of the dihydro compounds 4 produced the allcis-hexahydro isomers 5 which were consistently active in three assays against induced ventricular arrhythmias. On the other hand, the H9H9a-trans isomers, which were obtained by basic equilibration of the cis isomers, were less effective.

CiteXplore: 650662

DOI: 10.1021/jm00202a005

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