Potential anticancer agents. 16. Methotrexate analogues with a modified peptide side chain.

Basic Information

ID: ALA3244134

Journal: J Med Chem

Title: Potential anticancer agents. 16. Methotrexate analogues with a modified peptide side chain.

Authors: Suster DC, Tărnăuceanu E, Ionescu D, Dobre V, Niculescu-Duvăz I.

Abstract: Nine analogues of methotrexate, in which the side chain is modified by replacement of the terminal glutamyl moiety with other amino acids, were synthesized from 2,4-diamino-6-(chloromethyl)pteridine. None of these compounds exhibited significant activity against L1210.

CiteXplore: 722722

DOI: 10.1021/jm00209a015

Patent ID: