Document Report Card

ID: ALA3244216

Journal: J Med Chem

Title: Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol.

Authors: Ponpipom MM, Bugianesi RL, Shen TY.

Abstract: Chemical modification of the 4'-N position of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol (GlA1) in the form of 4'-N-acyl analogues, e.g., 3, led to no significant potency enhancement. The n-propylamino analogue 4 was more active against gram-positive bacteria but was less act vs. gram-negative bacteria. The intrinsic activity of the 6'-chloro analogue 15 like the antibiotic GlA1 was not high, but the antibacterial spectrum was broad with moderate activity against most resistant organisms.

CiteXplore: 621719

DOI: 10.1021/jm00200a016