Document Report Card

ID: ALA3244238

Journal: J Med Chem

Title: In search of anti-Trypanosoma cruzi drugs: new leads from a mouse model.

Authors: Kinnamon KE, Steck EA, Hanson WL, Chapman WL.

Abstract: Nine of 25 carefully selected compounds (from a stock of more than 200 000 chemical species amassed principally as a result of testing against other parasitic diseases) were found to have significant suppressive activity against the parasites in the blood of a Trypanosoma cruzi mouse model. Eight of these compounds evaluated in this model had suppressive activity equal to or greater than the reference compound, nifurtimox. For the first time, suppressive activity against T. cruzi is reported for a 7-aminoquinoline, a phosphonium salt, and TAC pamoate; The biological model is believed to be able to serve as a means of identifying other new "leads* in seeking drugs broadly effective against T=ruzi infections in man.

CiteXplore: 69024

DOI: 10.1021/jm00216a001