Document Report Card

ID: ALA3244265

Journal: J Med Chem

Title: Preparation and biological actions of some symmetrically N,N-disubstituted dopamines.

Authors: Cannon JG, Hsu FL, Long JP, Flynn JR, Costall B, Naylor RJ.

Abstract: The title compounds have been synthesized and evaluated for emetic effects in the dog, actions on the cardioaccelerator nerve in the cat, pecking in pigeons, and for behavioral effects following both peripheral and direct intracerebral injection into the nucleus accumbens and caudate-putamen of the rat. Generally, in the series studied, the N,N-diethyl and N,N-di-n-propyl congeners of dopamine displayed notably high degrees of activity. However, the test compounds exerted differing effects on peripheral and central dopamine receptors and in the area postrema. Differentiations of the activities of the different homologues within the brain were also shown.

CiteXplore: 564406

DOI: 10.1021/jm00201a002