Synthesis and antibacterial activity of 2'-substituted chelocardin analogues.

ID: ALA3244289

Journal: J Med Chem

Title: Synthesis and antibacterial activity of 2'-substituted chelocardin analogues.

Authors: Garmaise DL, Chu DT, Bernstein E, Inaba M, Stamm JM.

Abstract: Chelocardin (1) was condensed with numerous hydrazines, hydrazides, and anilines, yielding 2'-substituted derivatives with antibacterial spectra similar to the parent antibiotic. The hydrazone derivatives 9 and 10 and the two anilino derivatives 42 and 44 had more in vivo antibacterial activity than chelocardin.

CiteXplore: 379332

DOI: 10.1021/jm00191a018

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