Basic Information
ID: ALA3244424
Journal: J Med Chem
Title: Potential anticancer agents. 17. Analogues of methotrexate with a tripeptide side chain.
Authors: Suster DC, Tărnăuceanu E, Botez G, Dobre V, Niculescu-Duvăz I.
Abstract: Nine tripeptide analogues of methotrexate were synthesized from 2,4-diamino-6-(chloromethyl)pteridine. Only N-[N-[4-[2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]glycyl-DL-aspartic acid (1a) showed moderate activity against L1210 murine leukemia (ILS = 69%) and W 256 carcinosarcoma (TGI = 55%).
CiteXplore: 722723
DOI: 10.1021/jm00209a016
Patent ID: ┄
Associated Items: Associated Bioactivities Associated Assays Associated Compounds Associated Targets