Document Report Card

ID: ALA3259534

Journal: J Nat Prod

Title: Diterpenoids from Croton laui and their cytotoxic and antimicrobial activities.

Authors: Liu CP, Xu JB, Zhao JX, Xu CH, Dong L, Ding J, Yue JM.

Abstract: Fourteen new diterpenoids including clerodane (1-12), labdane (13), and norlabdane (14) types, as well as nine known analogues were isolated from the aerial parts of Croton laui. Their structures were established on the basis of spectroscopic analysis, and that of crotonolide H (11) was confirmed by single-crystal X-ray crystallography. Crotonolide A (1) exhibited moderate cytotoxicity against two tumor cell lines, HL-60 (human premyelocytic leukemia, IC50 9.42 μM) and P-388 (murine leukemia, IC50 7.45 μM), and crotonolide G (10) displayed significant antibacterial activity against a panel of Gram-positive bacteria.

CiteXplore: 24735527

DOI: 10.1021/np500042c