Document Report Card
Basic Information
ID: ALA3259612
Journal: Bioorg Med Chem Lett
Title: Design, synthesis, docking and anti-inflammatory evaluation of novel series of benzofuran based prodrugs.
Authors: Yadav P, Singh P, Tewari AK.
Abstract: Several new benzofuran derivatives were synthesized, via appropriate synthetic route as anti-inflammatory agents. The anti-inflammatory activity of the prepared compounds was evaluated using carrageenan rat model. Among the synthesized compounds, some compounds showed comparable anti-inflammatory activity to nimesulide, the standard drug taken for anti-inflammatory studies. Docking study of the prepared compounds was performed for the study of interaction of molecules with the active site of COX-2. Preliminary biological studies and docking gave an interesting insight, into the validity of employing benzofuran analogues as good anti-inflammatory agent.
CiteXplore: 24745964