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ID: ALA3259796

Journal: Bioorg Med Chem Lett

Title: Synthesis and in-vivo hypolipidemic activity of some novel substituted phenyl isoxazol phenoxy acetic acid derivatives.

Authors: Mokale SN, Nevase MC, Sakle NS, Dube PN, Shelke VR, Bhavale SA, Begum A.

Abstract: The present study was undertaken to evaluate in-vivo hypolipidemic activity of a novel series of 2-methyl-2-(substituted phenyl isoxazol)phenoxyacetic acid derivatives by triton induced hyperlipidemia in rats. The newly synthesized compounds 5a, 5d and 5g showed significant decrease in the serum TCH, TG, LDL and VLDL along with an increase in serum HDL levels as compared to standard drug Fenofibrate. The treated groups also showed significant decrease in the atherogenic index and increase in % protective activity compared to control group.

CiteXplore: 24703232

DOI: 10.1016/j.bmcl.2014.03.030