Document Report Card

ID: ALA3271948

Journal: J Med Chem

Title: Irreversible enzyme inhibitors. 200. Active-site-directed inhibitors of deoxycytidine kinase.

Authors: Ward AD, Baker BR.

Abstract: Forty-three pyrimidine derivatives, mainly containing the 4-aminopyrimidine system, have been prepared and evaluated as inhibitors of deoxycytidine kinase. The most effective inhibitors were 2-alkylthio-4-aminopyrimidines and 1-alky-1-cytosines. The best inhibitors in both groups were those with large alkyl substituents, which indicate that hydrophobic bonding is occurring, possibly in the same area adjacent to the active site.

CiteXplore: 189030

DOI: 10.1021/jm00211a018