Document Report Card

ID: ALA3272017

Journal: J Med Chem

Title: Adrenergic sulfonanilides. 4. Centrally active beta-adrenergic agonists.

Authors: Temple DL, Comer WT, Ferguson HC, Allen LE.

Abstract: The central nervous system (CNS) activities of a number of soterenol analogs have been investigated, and several of these compounds possessed potent morphine antagonistic and anorexiant properties. The CNS activity of these compounds was enhanced by certain lipophilic [e.g., 1,1-dimethyl-2-phenethyl (43) or cyclopropyl (40 and 44)] nitrogen substituents; however, minor structural changes on either the aromatic or side-chain moieties drastically reduced central activity. Toxicity in this series was related to the inherent alpha-adrenergic stimulating component (direct or indirect).

CiteXplore: 5607

DOI: 10.1021/jm00227a010