Document Report Card

ID: ALA3272075

Journal: J Med Chem

Title: Direct measurement of octanol-water partition coefficients by high-pressure liquid chromatography.

Authors: Mirrlees MS, Moulton SJ, Murphy CT, Taylor PJ.

Abstract: A technique is presented for the direct measurement of octanol-water partition coefficients by HPLC. The method involves running solutes in octanol-saturated water as the mobile phase against water-saturated octanol entrained on an inert support. Log P correlates linearly with log tc for a number of standards. The measurable range in log P (so far) is -0.3 to +3.7. A critical review of chromatographic methods in Hansch analysis is given.

CiteXplore: 1271403

DOI: 10.1021/jm00227a008