Antifertility agents. 12. Structure-activity relationship of 3,4-diphenylchromenes and -chromans.
Basic Information
ID: ALA3272087
Journal: J Med Chem
Title: Antifertility agents. 12. Structure-activity relationship of 3,4-diphenylchromenes and -chromans.
Authors: Ray S, Grover PK, Kamboj VP, Setty BS, Kar AB, Anand N.
Abstract: Synthesis and antiimplantation activity of variously substituted 2,2-dialkyl-3,4-diphenylchromenes and 3,4-cis- and trans-chromans derived from them are described. Pregnancy-inhibiting activity in rats was exhibited by a number of these compounds, which was particularly marked in the case of 3,4-trans-3-phenyl-4-p-(beta-pyrrolidinoethoxy)-phenyl-7-methoxychroman (32), the corresponding 2,2-dimethyl analog 34, and 3-phenyl-4-p-(beta-pyrrolidinoethoxy)phenyl-7-methoxychromene (26). The structure-activity relationship of these compounds is discussed.
CiteXplore: 1249807
DOI: 10.1021/jm00224a014
Patent ID: ┄