Antimalarials. 3. 1,2,4-Triazines.

ID: ALA3272167

Journal: J Med Chem

Title: Antimalarials. 3. 1,2,4-Triazines.

Authors: March LC, Bajwa GS, Lee J, Wasti K, Joullíe MM.

Abstract: The syntheses of a number of substituted 1,2,4-triazines as potential antimalarials are described. The structural requirements for antimalarial activity are discussed with reference to the substituents of a phenyl group in the 6 position and amino groups at the 3 and 5 positions. Of the compounds tested, 2,5, and 7 produced cures in mice infected with plasmodium berghei. Compounds 2(3,5-diamino-6-(4-trifluoromethylphenyl)-1,2,4-triazine),3,5,8,12,and 37 produced cures in chicks infected with Plasmodium gallinaceum.

CiteXplore: 781244

DOI: 10.1021/jm00228a024

Patent ID: ┄