Synthesis, antifertility activity, and protein binding affinity of 7(8 leads to 11 alpha)abeo steroids.
Basic Information
ID: ALA3272247
Journal: J Med Chem
Title: Synthesis, antifertility activity, and protein binding affinity of 7(8 leads to 11 alpha)abeo steroids.
Authors: Wani MC, Rector DH, White DH, Pitt CG, Kimmel GL.
Abstract: A series of 7(8 leads to 11 alpha)abeo steroids was synthesized by a modification of the previously described total synthesis of this class of compounds and evaluated for biological activity. In general, there was a marked reduction in the relative binding affinities of these compounds for the rabbit uterus estrogen and progestin receptor proteins. None of the compounds which were subjected to uterotropic, antiuterotropic, postcoital, progestational, antiprogestational, or antiandrogenic assays showed any significant activity.
CiteXplore: 850240
DOI: 10.1021/jm00214a017
Patent ID: ┄