Document Report Card

ID: ALA3272276

Journal: J Med Chem

Title: Synthesis and antimicrobial evaluation of substituted 5,6-dihydro-5-nitrouracils.

Authors: Long RA, Matthews TR, Robins RK.

Abstract: Reaction of 5-nitrouracil derivatives with sodium borohydride in methanol-water, followed by neutralization of the product with acid, has produced 5,6-dihydro-5-nitrouracil (5) 5,6-dihydro-6-dihydro-6-methyl-5-nitrouracil (7), 5,6-dihydro-5-nitro-1-(4-nitrophenyl)uracil (10), and 5,6-dihydro-5-nitro-1(beta-D-ribofuranuronic acid ethyl ester)uracil (12). In assays for antimicrobial activity using strains of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans, and Trichophyton mentagrophytes, significant inhibition of growth was not found.

CiteXplore: 823335

DOI: 10.1021/jm00230a020