Document Report Card

ID: ALA3286090

Journal: ACS Med Chem Lett

Title: Cryptocaryol Structure-Activity Relationship Study of Cancer Cell Cytotoxicity and Ability to Stabilize PDCD4.

Authors: Cuccarese MF, Wang Y, Beuning PJ, O'Doherty GA.

Abstract: The synthetic cryptocaryols A and B and a series of their analogues have been evaluated for their cytotoxicity and their ability to stabilize the tumor suppressor PDCD4. Cytotoxicities in the 3 to 30 μM range were found. Both the cytotoxicity and PDCD4 stabilizing ability were tolerant of large stereochemical changes to the molecule. Co-dosing studies with cryptocaryols A and B and several known cancer drugs showed no measuable enhancement in cancer drug cytotoxicity.

CiteXplore: 24900873

DOI: 10.1021/ml4005039