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ID: ALA3297703
Journal: Bioorg Med Chem
Title: Novel quinuclidinyl heteroarylcarbamate derivatives as muscarinic receptor antagonists.
Authors: Nagashima S, Matsushima Y, Hamaguchi H, Nagata H, Kontani T, Moritomo A, Koshika T, Takeuchi M.
Abstract: Herein, we describe the synthesis and pharmacological profiles of novel quinuclidinyl heteroarylcarbamate derivatives. Among them, the quinuclidin-4-yl thiazolylcarbamate derivative ASP9133 was identified as a promising long-acting muscarinic antagonist (LAMA) showing more selective inhibition of bronchoconstriction against salivation and more rapid onset of action in a rat model than tiotropium bromide.
CiteXplore: 24837158