Polyhydroxy cyclohexanols from a Dendrodochium sp. fungus associated with the sea cucumber Holothuria nobilis Selenka.
Basic Information
ID: ALA3297710
Journal: J Nat Prod
Title: Polyhydroxy cyclohexanols from a Dendrodochium sp. fungus associated with the sea cucumber Holothuria nobilis Selenka.
Authors: Xu DX, Sun P, Kurtán T, Mándi A, Tang H, Liu B, Gerwick WH, Wang ZW, Zhang W.
Abstract: Four cyclohexanol analogues, dendrodochols A-D (1-4), were isolated from a Dendrodochium sp. fungus associated with the sea cucumber Holothuria nobilis Selenka collected from the South China Sea. The structures were elucidated by means of detailed spectroscopic analysis. The absolute configurations were assigned using a solution TDDFT/ECD calculation approach and the modified Mosher's method. In an in vitro bioassay, these compounds exhibited no growth inhibition activity against the A549 and MG63 cell lines. Dendrodochols 1 and 3 exhibited modest antifungal activity against Candida strains, Cryptococcus neoformans, and Trichophyton rubrum, whereas 2 and 4 showed no activity against the tested strains.
CiteXplore: 24749951
DOI: 10.1021/np500024r
Patent ID: ┄