Document Report Card

ID: ALA3297724

Journal: J Nat Prod

Title: Carpatamides A-C, cytotoxic arylamine derivatives from a marine-derived Streptomyces sp.

Authors: Fu P, Johnson M, Chen H, Posner BA, MacMillan JB.

Abstract: Three new acylated arylamine derivatives (1-3), carpatamides A-C, were isolated from a marine-derived Streptomyces sp. based on activity screening against non-small-cell lung cancer (NSCLC). The structures of 1-3 were established on the basis of comprehensive spectroscopic analyses and chemical methods. Compounds 1 and 3 showed moderate cytotoxicity against NSCLC cell lines HCC366, A549, and HCC44 with IC50 values ranging from 2.2 to 8.4 μM.

CiteXplore: 24754815

DOI: 10.1021/np500207p