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ID: ALA3297732
Journal: Bioorg Med Chem Lett
Title: Aryl-substituted aminobenzimidazoles targeting the hepatitis C virus internal ribosome entry site.
Authors: Ding K, Wang A, Boerneke MA, Dibrov SM, Hermann T.
Abstract: We describe the exploration of N1-aryl-substituted benzimidazoles as ligands for the hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA. The design of the compounds was guided by the co-crystal structure of a benzimidazole viral translation inhibitor in complex with the RNA target. Structure-binding activity relationships of aryl-substituted benzimidazole ligands were established that were consistent with the crystal structure of the translation inhibitor complex.
CiteXplore: 24856063