Document Report Card

ID: ALA3351224

Journal: ACS Med Chem Lett

Title: Discovery of Highly Potent Dual CysLT1 and CysLT2 Antagonist.

Authors: Itadani S, Takahashi S, Ima M, Sekiguchi T, Fujita M, Nakayama Y, Takeuchi J.

Abstract: The benzoxazine derivative, (2S)-4-(3-carboxypropyl)-8-{[4-(4-phenylbutoxy)benzoyl]amino}-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid (19, ONO-2050297), was identified as the first potent dual CysLT1 and CysLT2 antagonist with IC50 values of 0.017 μM (CysLT1) and 0.00087 μM (CysLT2), respectively.

CiteXplore: 25408836

DOI: 10.1021/ml500298y