Curcumolide, a unique sesquiterpenoid with anti-inflammatory properties from Curcuma wenyujin.
Basic Information
ID: ALA3351270
Journal: Bioorg Med Chem Lett
Title: Curcumolide, a unique sesquiterpenoid with anti-inflammatory properties from Curcuma wenyujin.
Authors: Dong J, Shao W, Yan P, Cai X, Fang L, Zhao X, Lin W, Cai Y.
Abstract: Curcumolide, a novel sesquiterpenoid with a unique 5/6/5 tricyclic skeleton, was isolated from Curcuma wenyujin. The structure and absolute configuration were elucidated by extensive NMR, ECD data analysis, and a single-crystal X-ray study. This molecule exhibited significant anti-inflammatory effects in LPS-induced RAW 264.7 macrophages. It suppressed LPS-induced NF-κB activation, including the nuclear translocation and DNA binding activity of NF-κB, and decreased tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β), nitric oxide (NO) and reactive oxygen species (ROS) production. Therefore, Curcumolide may have therapeutic potential for treating inflammatory diseases by inhibiting NF-κB activation and pro-inflammatory mediator production.
CiteXplore: 25515561
DOI: 10.1016/j.bmcl.2014.11.075
Patent ID: ┄