Document Report Card

ID: ALA3351361

Journal: J Med Chem

Title: Fragment-based screening of the bromodomain of ATAD2.

Authors: Harner MJ, Chauder BA, Phan J, Fesik SW.

Abstract: Cellular and genetic evidence suggest that inhibition of ATAD2 could be a useful strategy to treat several types of cancer. To discover small-molecule inhibitors of the bromodomain of ATAD2, we used a fragment-based approach. Fragment hits were identified using NMR spectroscopy, and ATAD2 was crystallized with three of the hits identified in the fragment screen.

CiteXplore: 25314628

DOI: 10.1021/jm501035j