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ID: ALA3351456
Journal: Bioorg Med Chem
Title: Synthesis and antiviral activities of 3-deaza-3-fluoroaristeromycin and its 5' analogues.
Authors: Chen Q, Liu C, Komazin G, Bowlin TL, Schneller SW.
Abstract: The naturally occurring adenine based carbocyclic nucleosides aristeromycin and neplanocin A and their 3-deaza analogues have found a prominent place in the search for diverse antiviral activity agent scaffolds because of their ability to inhibit S-adenosylhomocysteine (AdoHcy) hydrolase. Following the lead of these compounds, their 3-deaza-3-fluoroaristeromycin analogues have been synthesized and their effect on S-adenosylhomocysteine hydrolase and RNA and DNA viruses determined.
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