Basic Information
ID: ALA3351477
Journal: Bioorg Med Chem
Title: A C-14 labeled Py-Im polyamide localizes to a subcutaneous prostate cancer tumor.
Authors: Raskatov JA, Puckett JW, Dervan PB.
Abstract: In an effort to quantitate Py-Im polyamide concentrations in vivo, we synthesized the C-14 radioactively labeled compounds 1-3, and investigated their tumor localization in a subcutaneous xenograft model of prostate cancer (LNCaP). Tumor concentrations were compared with representative host tissues, and exhibited a certain degree of preferential localization to the xenograft. Compound accumulation upon repeated administration was measured. Py-Im polyamide 1 was found to accumulate in LNCaP tumors at concentrations similar to the IC50 value for this compound in cell culture experiments.
CiteXplore: 24780272
DOI: 10.1016/j.bmc.2014.04.010
Patent ID: ┄
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