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ID: ALA3351516
Journal: Bioorg Med Chem Lett
Title: Efficient synthesis of eudistomin U and evaluation of its cytotoxicity.
Authors: Roggero CM, Giulietti JM, Mulcahy SP.
Abstract: Eudistomin U is a member of a subclass of naturally occurring indole alkaloids known as β-carbolines. These molecules are reported to have diverse biological activity and high binding affinity to DNA, which make them attractive targets for total synthesis. We describe an efficient, five-step synthesis of eudistomin U by employing two key reactions: a Bischler-Napieralski cyclization and a Suzuki cross coupling. We also describe the cytotoxicity of eudistomin U against various cancer cell lines and human pathogens, in which we observed potent antibacterial activity against Gram-positive bacteria.
CiteXplore: 24930832