Identification of novel phenyl butenonyl C-glycosides with ureidyl and sulfonamidyl moieties as antimalarial agents.
Basic Information
ID: ALA3351535
Journal: ACS Med Chem Lett
Title: Identification of novel phenyl butenonyl C-glycosides with ureidyl and sulfonamidyl moieties as antimalarial agents.
Authors: Ramakrishna KK, Gunjan S, Shukla AK, Pasam VR, Balaramnavar VM, Sharma A, Jaiswal S, Lal J, Tripathi R, Anubhooti, Ramachandran R, Tripathi RP.
Abstract: A new series of C-linked phenyl butenonyl glycosides bearing ureidyl(thioureidyl) and sulfonamidyl moieties in the phenyl rings were designed, synthesized, and evaluated for their in vitro antimalarial activities against Plasmodium falciparum 3D7 (CQ sensitive) and K1 (CQ resistant) strains. Among all the compounds screened the C-linked phenyl butenonyl glycosides bearing sulfonamidyl moiety (5a) and ureidyl moiety in the phenyl ring (7d and 8c) showed promising antimalarial activities against both 3D7 and K1 strains with IC50 values in micromolar range and low cytotoxicity offering new HITS for further exploration.
CiteXplore: 25147607
DOI: 10.1021/ml500211c
Patent ID: ┄