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ID: ALA3351568
Journal: Bioorg Med Chem Lett
Title: 2-Aminobenzoxazole ligands of the hepatitis C virus internal ribosome entry site.
Authors: Rynearson KD, Charrette B, Gabriel C, Moreno J, Boerneke MA, Dibrov SM, Hermann T.
Abstract: 2-Aminobenzoxazoles have been synthesized as ligands for the hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA. The compounds were designed to explore the less basic benzoxazole system as a replacement for the core scaffold in previously discovered benzimidazole viral translation inhibitors. Structure-activity relationships in the target binding of substituted benzoxazole ligands were investigated.
CiteXplore: 24930829