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ID: ALA3351575
Journal: Bioorg Med Chem Lett
Title: Halogenated diarylacetylenes repress c-myc expression in cancer cells.
Authors: Sviripa VM, Zhang W, Kril LM, Liu AX, Yuan Y, Zhan CG, Liu C, Watt DS.
Abstract: Halogenated diarylacetylenes that possess fluorine or chlorine substituents in one aryl ring and N-methylamino or N,N-dimethylamino in the other aryl ring inhibit the proliferation of LS174T colon cancer cells through the repression of c-myc expression and induction of the cyclin-dependent kinase inhibitor-1 (i.e., p21(Wif1/Cip1)) and represent potentially useful antineoplastic agents.
CiteXplore: 24930834