Document Report Card

ID: ALA3351629

Journal: J Med Chem

Title: Modulators of the nuclear receptor retinoic acid receptor-related orphan receptor-γ (RORγ or RORc).

Authors: Fauber BP, Magnuson S.

Abstract: As the biology surrounding the nuclear receptor retinoic acid receptor-related orphan receptor-gamma (RORγ or RORc) continues to evolve, significant effort has been invested in discovering modulators of this potentially important target for the treatment of metabolic and immunological diseases. Several major pharmaceutical and biotechnology companies have disclosed RORc inhibitors or partnered with other players in the field. In this perspective, we discuss both the biology and the underlying structural biology of RORc, and summarize the RORc modulators disclosed in the scientific and patent literature.

CiteXplore: 24502334

DOI: 10.1021/jm401901d