Document Report Card

ID: ALA3351633

Journal: J Nat Prod

Title: Anithiactins A-C, modified 2-phenylthiazoles from a mudflat-derived Streptomyces sp.

Authors: Kim H, Yang I, Patil RS, Kang S, Lee J, Choi H, Kim MS, Nam SJ, Kang H.

Abstract: Intensive investigation of the chemical components of a Streptomyces sp. isolated from mudflat sediments collected on the southern coast of the Korean peninsula led to the isolation of three new compounds, anithiactins A-C (1-3). The chemical structures of anithiactins A and C were determined by interpretation of NMR data analyses, while the chemical structure of anithiactin B was established from a combination of NMR spectroscopic and crystallographic data analyses. The structure of anithiactin A was also confirmed by total synthesis. These three anithiactins displayed moderate acetylcholinesterase inhibitory activity with no significant cytotoxicity.

CiteXplore: 25455147

DOI: 10.1021/np500558b