Synthesis and cytotoxic evaluation of novel ester-triazole-linked triterpenoid-AZT conjugates.
Basic Information
ID: ALA3351916
Journal: Bioorg Med Chem Lett
Title: Synthesis and cytotoxic evaluation of novel ester-triazole-linked triterpenoid-AZT conjugates.
Authors: Dang Thi TA, Kim Tuyet NT, Pham The C, Thanh Nguyen H, Ba Thi C, Doan Duy T, D'hooghe M, Van Nguyen T.
Abstract: Betulinic acid and analogous naturally occurring triterpenoid acids were transformed into the corresponding propargyl esters and subsequently deployed as substrates for a click chemistry-mediated coupling with azidothymidine (AZT) en route to novel 1,2,3-triazole-tethered triterpenoid-AZT conjugates. Twelve new hybrids were thus prepared and assessed in terms of their cytotoxic activity, revealing an interesting anticancer activity of five triterpenoid-AZT hybrids on KB and Hep-G2 tumor cell lines.
CiteXplore: 25442310
DOI: 10.1016/j.bmcl.2014.09.079
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