Probing linker design in citric acid-ciprofloxacin conjugates.
Basic Information
ID: ALA3351986
Journal: Bioorg Med Chem
Title: Probing linker design in citric acid-ciprofloxacin conjugates.
Authors: Milner SJ, Snelling AM, Kerr KG, Abd-El-Aziz A, Thomas GH, Hubbard RE, Routledge A, Duhme-Klair AK.
Abstract: A series of structurally related citric acid-ciprofloxacin conjugates was synthesised to investigate the influence of the linker between citric acid and ciprofloxacin on antibacterial activities. Minimum inhibitory concentrations (MICs) were determined against a panel of reference strains and clinical isolates of bacteria associated with infection in humans and correlated with the DNA gyrase inhibitory activity. The observed trend was rationalised by computational modelling.
CiteXplore: 24794750
DOI: 10.1016/j.bmc.2014.04.009
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