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ID: ALA3351995

Journal: Bioorg Med Chem Lett

Title: β-Nitro substituted carboxylic acids and their cytotoxicity.

Authors: Csuk R, Heller L, Siewert B, Gutnov A, Seidelmann O, Wendisch V.

Abstract: β-Nitro-substituted ethyl carboxylates are a new class of cytotoxic agents; they can be easily obtained in fair to good yields in a single-step reaction by a Pd-catalyzed asymmetric conjugate addition of aryl boronic acids to 2-nitro-acrylates. Of all the tested derivatives, 2-(4-chlorophenyl)-3-nitropropionic acid ethyl ester (6) is most cytotoxic especially against the human ovarian cancer cell line A2780 therefore making this compound an interesting candidate for further investigations.

CiteXplore: 25001484

DOI: 10.1016/j.bmcl.2014.06.021