Effect of acyclic monoterpene alcohols and their derivatives on TRP channels.
Basic Information
ID: ALA3352014
Journal: Bioorg Med Chem Lett
Title: Effect of acyclic monoterpene alcohols and their derivatives on TRP channels.
Authors: Ortar G, Schiano Moriello A, Morera E, Nalli M, Di Marzo V, De Petrocellis L.
Abstract: A series of thirty-six geraniol, nerol, citronellol, geranylamine, and nerylamine derivatives was synthesized and tested on TRPA1, TRPM8, and TRPV1 channels. Most of them acted as strong modulators of TRPA1 channels with EC50 and/or IC50 values <1 μM. None was able to significantly activate TRPM8 channels, while thirteen of them behaved as 'true' TRPM8 antagonists. Little or no effect was generally observed on TRPV1 channels. Some of the compounds examined, that is, compounds 1d,g,n, 2c,d,h,i,o, 3b,e exhibited an appreciable selectivity for TRPA1 subtype.
CiteXplore: 25455494
DOI: 10.1016/j.bmcl.2014.10.012
Patent ID: ┄