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ID: ALA3352123
Journal: Bioorg Med Chem Lett
Title: Structure activity relationship study of curcumin analogues toward the amyloid-beta aggregation inhibitor.
Authors: Endo H, Nikaido Y, Nakadate M, Ise S, Konno H.
Abstract: Inhibition of the amyloid β aggregation process could possibly prevent the onset of Alzheimer's disease. In this article, we report a structure-activity relationship study of curcumin analogues for anti amyloid β aggregation activity. Compound 7, the ideal amyloid β aggregation inhibitor in vitro among synthesized curcumin analogues, has not only potent anti amyloid β aggregation effects, but also water solubility more than 160 times that of curcumin. In addition, new approaches to improve water solubility of curcumin-type compounds are proposed.
CiteXplore: 25467149