Synthesis and biological activity of 5-(4-methoxyphenyl)-oxazole derivatives.

ID: ALA3352244

Journal: Bioorg Med Chem Lett

Title: Synthesis and biological activity of 5-(4-methoxyphenyl)-oxazole derivatives.

Authors: Yamamuro D, Uchida R, Ohtawa M, Arima S, Futamura Y, Katane M, Homma H, Nagamitsu T, Osada H, Tomoda H.

Abstract: 5-(4'-Methoxyphenyl)-oxazole (MPO), originally reported as a synthetic compound, was isolated from fungal culture broth as an inhibitor of hatch and growth of Caenorhabditis elegans. Nineteen MPO derivatives were chemically synthesized, but showed no effect on C. elegans hatch and growth. These findings strongly suggested that the whole structure of MPO is essential for anti-C. elegans activity.

CiteXplore: 25488842

DOI: 10.1016/j.bmcl.2014.11.042

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