Anti-inflammatory ursane- and oleanane-type triterpenoids from Vitex negundo var. cannabifolia.
Basic Information
ID: ALA3352517
Journal: J Nat Prod
Title: Anti-inflammatory ursane- and oleanane-type triterpenoids from Vitex negundo var. cannabifolia.
Authors: Li MM, Su XQ, Sun J, Gu YF, Huang Z, Zeng KW, Zhang Q, Zhao YF, Ferreira D, Zjawiony JK, Li J, Tu PF.
Abstract: Six new polyoxygenated triterpenoids, cannabifolins A-F (1-6), and eight known triterpenoids, 7-14, were isolated from the leaves of Vitex negundo var. cannabifolia. The absolute configuration of cannabifolin A (1) was determined by single-crystal X-ray crystallographic analysis. Compounds 1 and 2 represent a class of rare natural pentacyclic triterpenoids bearing cis-fused C/D rings and are the first examples of 12,19-epoxy ursane- and oleanane-type triterpenoids. Compounds 3, 7, 8, and 14 exhibited inhibition of nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages with IC50 values in the range 24.9-40.5 μM.
CiteXplore: 25245917
DOI: 10.1021/np500509q
Patent ID: ┄