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ID: ALA3352528

Journal: Bioorg Med Chem Lett

Title: Ejection of structural zinc leads to inhibition of γ-butyrobetaine hydroxylase.

Authors: Rydzik AM, Brem J, Struwe WB, Kochan GT, Benesch JL, Schofield CJ.

Abstract: γ-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate and Fe(II) dependent oxygenase that catalyses an essential step during carnitine biosynthesis in animals. BBOX is inhibited by ejection of structural zinc by a set of selenium containing analogues. Previous structural analyses indicated that an undisrupted N-terminal zinc binding domain of BBOX is required for catalysis. Ebselen is a relatively potent BBOX inhibitor, an observation which may in part reflect its cardioprotective properties.

CiteXplore: 25266780

DOI: 10.1016/j.bmcl.2014.09.035