Document Report Card

Basic Information

ID: ALA3352665

Journal: Eur J Med Chem

Title: Trends in research of antitrypanosomal agents among synthetic heterocycles.

Authors: Kryshchyshyn A, Kaminskyy D, Grellier P, Lesyk R.

Abstract: To date treatment of trypanosomiasis urgently requires new effective and non-toxic drugs. The article covers some of the achievements in the search for new antitrypanosomal agents; also the "validated" biological targets used in the antitrypanosomal agents design are outlined. The major part of the manuscript focuses on the synthetic small molecules, such as thiosemicarbazone and thiazole (as their cyclic analogues) derivatives, benzofuran derivatives, heterocycles bearing nitro group etc. Also, the attractiveness of metal complexes and well known drugs as sources for antitrypanosomal agent design is discussed.

CiteXplore: 25072876

DOI: 10.1016/j.ejmech.2014.07.092