Document Report Card

ID: ALA3390837

Journal: Medchemcomm

Title: Bridged tetrahydroisoquinolines as selective NADPH oxidase 2 (Nox2) inhibitors.

Authors: Cifuentes-Pagano E, Saha J, Csányi G, Ghouleh IA, Sahoo S, Rodríguez A, Wipf P, Pagano PJ, Skoda EM.

Abstract: (1SR,4RS)-3,3-Dimethyl-1,2,3,4-tetrahydro-1,4-(epiminomethano)naphthalenes were synthesized in 2-3 steps from commercially available materials and assessed for specificity and effectiveness across a range of Nox isoforms. The N-pentyl and N-methylenethiophene substituted analogs 11g and 11h emerged as selective Nox2 inhibitors with cellular IC50 values of 20 and 32 μM, respectively.

CiteXplore: 24466406

DOI: 10.1039/c3md00061c