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ID: ALA3392966
Journal: Bioorg Med Chem
Title: Antiproliferative activity of synthetic fatty acid amides from renewable resources.
Authors: dos Santos DS, Piovesan LA, D'Oca CR, Hack CR, Treptow TG, Rodrigues MO, Vendramini-Costa DB, Ruiz AL, de Carvalho JE, D'Oca MG.
Abstract: In the work, the in vitro antiproliferative activity of a series of synthetic fatty acid amides were investigated in seven cancer cell lines. The study revealed that most of the compounds showed antiproliferative activity against tested tumor cell lines, mainly on human glioma cells (U251) and human ovarian cancer cells with a multiple drug-resistant phenotype (NCI-ADR/RES). In addition, the fatty methyl benzylamide derived from ricinoleic acid (with the fatty acid obtained from castor oil, a renewable resource) showed a high selectivity with potent growth inhibition and cell death for the glioma cell line-the most aggressive CNS cancer.
CiteXplore: 25510639