Document Report Card

ID: ALA3393060

Journal: J Med Chem

Title: Inhibitors of c-Jun N-terminal kinases: an update.

Authors: Koch P, Gehringer M, Laufer SA.

Abstract: The c-Jun N-terminal kinases (JNKs) are serine/threonine kinases implicated in the pathogenesis of various diseases. Recent advances in the development of novel inhibitors of JNKs will be reviewed. Significant progress in the design of JNK inhibitors displaying selectivity versus other kinases has been achieved within the past 4 years. However, the development of isoform selective JNK inhibitors is still an open task.

CiteXplore: 25415535

DOI: 10.1021/jm501212r