Synthesis and evaluation of the diarylthiourea analogs as novel anti-cancer agents.
Basic Information
ID: ALA3397006
Journal: Bioorg Med Chem Lett
Title: Synthesis and evaluation of the diarylthiourea analogs as novel anti-cancer agents.
Authors: Liu S, Louie MC, Rajagopalan V, Zhou G, Ponce E, Nguyen T, Green L.
Abstract: Ten p-nitrodiarylthiourea analogs were designed, synthesized and evaluated in breast (MCF-7, T-47D, MDA-MB-453) and prostate (DU-145, PC-3, LNCaP) cancer cell lines for their anticancer activities. The majority of the compounds were able to inhibit the growth of these six cancer cell lines at low micromolar concentrations. Compound 7 was found to be the most potent anticancer agent in this series with GI50 values of 3.16μM for MCF-7, 2.53μM for T-47D, 4.77μM for MDA-MB-453 breast cancer lines and 3.54μM for LNCaP prostate cancer cell line. These GI50 values were comparable to the parent compound, SHetA2.
CiteXplore: 25701251
DOI: 10.1016/j.bmcl.2015.01.042
Patent ID: ┄